IL-23 is a heterodimeric pro-inflammatory cytokine secreted by dendritic cells and macrophages that belongs to the IL-12 family.It has pro-inflammatory effects and is a key cytokine and upstream regulatory cytokine involved in protective immune responses, stimulating the differentiation and proliferation of downstream effectors such as Th17 cells.I

Abstract Osteoarthritis (OA) poses a significant challenge in orthopedics.Inflammatory pathways are regarded as central mechanisms in the onset and progression of OA.Growing evidence suggests that senescence acts as a mediator in inflammation-induced OA.Given the lack of effective treatments for OA, there is an urgent need for a clearer understandi

Introduction: Atypical mycobacteria can survive in conditions that make them hard to eradicate, despite using the standard decontamination procedures and protocols.Thus, errors in sterilisation techniques for laparoscopic instruments can be responsible for outbreaks caused by such bacteria and make it a problem mainly affecting developing countries

This paper describes the role of an American organization, the Jewish Labor Committee (JLC), in the support of Jewish people in Poland during World War II.In the context of the division and occupation of Poland by the USSR and by Nazi Germany, the JLC’s help materialized in two ways: relief (generally in kind) was sent to Jewish refugees in Russi

A numerical method for detection of unstable periodic orbits on attractors here of nonlinear models is proposed.  The method requires similar techniques to data assimilation.  This fact facilitates its implementation for geophysical models.  This method was used to find numerically several low-period orbits for the barotropic ocean m